The number of small diameter urine spot was increased 24 hours after CYP in WT, but not in FAAH KO mice (A, two way ANOVA results: Finteraction = 12.9, p < 0.05; Fgenotype = 14.3, p < 0.05; Ftreatment = 10.3, p < 0.05). Treatment with saline did not affect peripheral mechanical sensitivity (B). However, the mechanical sensitivity threshold was reduced 24 hours after CYP in WT, but not in FAAH KO, mice (B, two way ANOVA results: Finteraction = 12.4, p < 0.01; Fgenotype = 36.2, p < 0.0001; Ftreatment = 7.2, p < 0.05). Mean ± S.E.M. n = 6–8. **: p < 0.01 vs saline treated.