Table I.
Compound | EC50 (μM)1 | Structure |
---|---|---|
15d-PGJ2 | ~20 | |
PGJ2 | ~40 | |
PGA1 | ~240 | |
PGD2 | ~400 | |
PGE2 | >1000 | |
PGF2α | >1000 | |
Cyclopentene | >1000 | |
Cyclopentanone | >1000 | |
2-cyclopentenone | ~510 | |
4-cyclopenten-1,3-dione | ~60 | |
CAY10410 | >1000 |
RAW264.7 cells were treated 30 min with variable concentrations of compound. Cells were challenged with LT (1 μg/mL, 1.5 h) and cell viability was measured by MTT staining. At least two experiments represented by a single shown study were used to generate an EC50 value for each compound’s ability to inhibit LT-induced pyroptosis.