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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: J Immunol. 2015 Feb 13;194(6):2776–2785. doi: 10.4049/jimmunol.1401611

Table I.

EC50 values of structural variants of 15d-PGJ2

Compound EC50 (μM)1 Structure
15d-PGJ2 ~20 graphic file with name nihms654857t1.jpg
PGJ2 ~40 graphic file with name nihms654857t2.jpg
PGA1 ~240 graphic file with name nihms654857t3.jpg
PGD2 ~400 graphic file with name nihms654857t4.jpg
PGE2 >1000 graphic file with name nihms654857t5.jpg
PGF2α >1000 graphic file with name nihms654857t6.jpg
Cyclopentene >1000 graphic file with name nihms654857t7.jpg
Cyclopentanone >1000 graphic file with name nihms654857t8.jpg
2-cyclopentenone ~510 graphic file with name nihms654857t9.jpg
4-cyclopenten-1,3-dione ~60 graphic file with name nihms654857t10.jpg
CAY10410 >1000 graphic file with name nihms654857t11.jpg
1

RAW264.7 cells were treated 30 min with variable concentrations of compound. Cells were challenged with LT (1 μg/mL, 1.5 h) and cell viability was measured by MTT staining. At least two experiments represented by a single shown study were used to generate an EC50 value for each compound’s ability to inhibit LT-induced pyroptosis.