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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: J Immunol. 2015 Feb 13;194(6):2942–2953. doi: 10.4049/jimmunol.1402610

Figure 9. Proposed model of TGFβ1 and IL-10 function and regulation in CTCL cells.

Figure 9

In CTCL cells, proteasome inhibition by BZ inhibits expression of the NFκB-dependent immunosuppressive cytokines IL-10 and TGFβ1. However, while the TGFβ1 expression is regulated by the IκBα-dependent canonical pathway, the IL-10 expression is regulated by the IκBα-independent non-canonical pathway. Suppression of TGFβ1 in CTCL cells induces apoptosis and IL-8 and IL-17 expression, while concomitantly inhibiting CXCR4 expression and CTCL migration.