Skip to main content
. Author manuscript; available in PMC: 2016 Mar 5.
Published in final edited form as: Mol Cell. 2015 Feb 19;57(5):901–911. doi: 10.1016/j.molcel.2015.01.016

Figure 1. Structure of UCH37 and ubiquitin complex.

Figure 1

(A) UCH37, ribbon representation, as seen in the RPN13 complexes. The catalytic C88 is shown as orange spheres; active site crossover loop (ASCL), yellow. Helices α8-α11 that comprise the CTD are labeled.

(B) Surface representation of UCH37 with ubiquitin (blue-gray) from the RPN13 complex and structures of ubiquitin in complex with other UCH family members (Boudreaux et al., 2010; Johnston et al., 1999; Misaghi et al., 2005; Morrow et al., 2013) following superposition on the UCH domains. The ubiquitin C-terminus is indicated with an arrow.

(C) Sequence and secondary structures of murine UCH37 isoform 2 (RPN13 and ubiquitin complex) and human UCH37 isoform 2 (NFRKB complex).