Skip to main content
. Author manuscript; available in PMC: 2016 Mar 5.
Published in final edited form as: Mol Cell. 2015 Feb 19;57(5):901–911. doi: 10.1016/j.molcel.2015.01.016

Figure 5. Inhibition of UCH37 by NFRKB.

Figure 5

(A) The L8 loop of ubiquitin and the F100 loop of NFRKB bind to the same pocket on UCH37.

(B) Ribbon diagram, same as Fig. 3B but including RPN13, NFRKB, and ubiquitin.

(C) Contacts of the NFRKB C-terminal helix with the UCH37UCH domain.

(D) Superposition of the UCH37 active sites for NFRKB (solid/inactive conformation) and RPN13 (semitransparent/active conformation) following overlap on the UCH domains.