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. Author manuscript; available in PMC: 2016 Mar 1.

Published in final edited form as: Cancer Prev Res (Phila). 2015 Feb 13;8(3):231–239. doi: 10.1158/1940-6207.CAPR-14-0181-T

Rats bearing MNU-Induced cancers were treated with vehicle or metformin (150 mg/kg BW/day) for a period of 7 days. At that time, rats were sacrificed and tumors removed. Tissue slices were prepared and stained as described in Material and Methods. Representative staining is shown. (A) Shows alterations of expression in the various phosphorylated proteins in control mammary tumors following short term metformin exposure; (B) Shows IHC slides staining for the various phosphoproteins, DAPI and a merged image.

Rats bearing MNU-Induced cancers were treated with vehicle or metformin (150 mg/kg BW/day) for a period of 7 days. At that time, rats were sacrificed and tumors removed. Tissue slices were prepared and stained as described in Material and Methods. Representative staining is shown. (A) Shows alterations of expression in the various phosphorylated proteins in control mammary tumors following short term metformin exposure; (B) Shows IHC slides staining for the various phosphoproteins, DAPI and a merged image.