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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Cancer Prev Res (Phila). 2015 Feb 13;8(3):231–239. doi: 10.1158/1940-6207.CAPR-14-0181-T

Figure 4. Effects of Metformin on Expression of Proliferation Related Biomarkers.

Figure 4

Rats were treated as described in Materials and Methods. Both expression of proliferation related genes and Ki67 values were determined in formalin-fixed samples. (A) Effects of metformin and a positive control (tamoxifen) on proliferation index in mammary cancers. Results are based on counting at least 2,000 cells for each of the tumors. The Ki67 labeling index was significantly increased in cancers treated with metformin and decreased in cancers treated with tamoxifen (P<.05) when compared with controls. (B) Effects of metformin and tamoxifen on expression of proliferation related genes.