Table 1. Mean Plasma Concentration-Time Data and Pharmacokinetic Estimates.
Time (h) | Group 1 (Day 1) | Group 2 (Day 14) |
---|---|---|
Mean Plasma Concentration (ng/ml) (± SD) | Mean Plasma Concentration (ng/ml) (± SD) | |
0 | 0 | 97 ± 42 |
1 | 7470 ± 790 | 6720 ± 390 |
2 | 7080 ± 1490 | 4610 ± 1090 |
4 | 4920 ± 1410 | 5030 ± 1240 |
8 | 1430 ± 570 | 1470 ± 480 |
24 | 70 ± 14 | 129 ± 44 |
Pharmacokinetic Estimates | ||
| ||
Tmax (h) | 1 | 1 |
Cmax (ng/ml) | 7470 | 6720 |
Half-life (h) | 3.7 | 4.6 |
AUC0-24h (ng/ml × h) | 47670 | 44560 |