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| Time (h) | Group 1 (Day 1) | Group 2 (Day 14) |
|---|---|---|
| Mean Plasma Concentration (ng/ml) (± SD) | Mean Plasma Concentration (ng/ml) (± SD) | |
| 0 | 0 | 97 ± 42 |
| 1 | 7470 ± 790 | 6720 ± 390 |
| 2 | 7080 ± 1490 | 4610 ± 1090 |
| 4 | 4920 ± 1410 | 5030 ± 1240 |
| 8 | 1430 ± 570 | 1470 ± 480 |
| 24 | 70 ± 14 | 129 ± 44 |
| Pharmacokinetic Estimates | ||
|
| ||
| Tmax (h) | 1 | 1 |
| Cmax (ng/ml) | 7470 | 6720 |
| Half-life (h) | 3.7 | 4.6 |
| AUC0-24h (ng/ml × h) | 47670 | 44560 |
