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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Mol Psychiatry. 2015 Jan 20;20(3):377–387. doi: 10.1038/mp.2014.184

Figure 3. Attenuation of anxiety/depression-like behaviors in stressed mice after treatment with GSK2606414, an EIF2A-mediated inhibitor of cellular stress response.

Figure 3

(A) Experimental design. (B) Anxiety/depressive-like behaviors in the NSF test were increased after UCMS treatment, and GSK2606414 treatment significantly eliminated UCMS effects on behaviors. (C) The same effects of UCMS and GSK2606414 on emotionality were confirmed with emotionality Z-scores. (D–F) No treatments affected overall locomotion, body weight, or post-NSF feeding at home cage. *p<0.05, **p<0.01, ***p<0.005, ****p<0.001. Error bars represent the standard error of the mean (n =8–12/group).