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. Author manuscript; available in PMC: 2016 Jan 20.
Published in final edited form as: Immunity. 2015 Jan 20;42(1):95–107. doi: 10.1016/j.immuni.2014.12.022

Figure 3. Conservation of TCR contact amino acids predicts p:I-Ab cross-reactivity.

Figure 3

(A) Contour plots showing parent p:I-Ab tetramer staining (indicated on the Y-axes) of spleen and lymph node cells from mice primed 11 days earlier with CFA alone (no peptide), homologous bacterial peptide, or parental peptide. CD44hi tetramer-binding cells are indicated in the rectangular gates.

(B) Average number of 3K:I-Ab+, LLO:I-Ab+, GP66:I-Ab+, or 2W:I-Ab+ CD4+ T cells 11 days after priming with the indicated peptides emulsified in CFA (± SEM, n = 3 mice) from 1 experiment, which was representative of another.