Table 1.

Mean absolute and relative change in Version 4 AOM-SOS score from Day 1 to Day 2 according to parental global rating of change (GRC) score.

Parental global rating of change from Day 1 to Day 2	Mean absolute change in Version 4 AOM-SOS score from Day 1 to Day 2 (mean relative change)*
	All Children N = 256†	Children with the highest quartile baseline AOM-SOS score (≥8) N = 82	Children with the lowest quartile baseline AOM-SOS score (≤5) N = 97
No appreciable change (GRC score −1, 0, or +1)	2.2 (35%) N=136	3.0 (34%) N=35	1.2 (29%) N=60
Small degree of improvement (GRC score 2 or 3)	3.8 (55%) N=74	4.8 (55%) N=32	2.5 (56%) N=21
Moderate degree of improvement (GRC score 4 or 5)	4.3 (63%) N=33	6.1 (68%) N=13	2.3 (57%) N=10
Large degree of improvement (GRC score 6 or 7)	4.9 (85%) N=13	7.5 (88%) N=2	3.8 (84%) N=6

AOM-SOS denotes Acute Otitis Media Severity of Symptoms.

^*Day 1 was the day of enrollment. Relative change in AOM-SOS score from Day 1 to Day 2 = [Day 2 score minus Day 1 score]/Day 1 score.

^†Not included in this table are 16 children with missing AOM-SOS and/or GRC scores and 5 children whose condition worsened from baseline to Day 2.

The shaded row shows the estimated minimal important difference (MID).