Table 1.

Individual SNP associations with risk of breast cancer

SNP	Gene	Frequency of low vitamin D allele	# Low vitamin D alleles	# Cases	# Controls	OR (95% CI)*	p-value†	p for heterogeneity across cohorts§
rs2282679	GC	0.28
TT			0	4,531	5,100	1.0 (ref)
GT			1	3,412	4,104	0.94 (0.88 – 1.00)
GG			2	713	781	1.03 (0.92 – 1.15)	0.08
Additive (per allele)						0.98 (0.94 – 1.03)	0.39	0.10
rs6013897	CYP24A1	0.21
TT			0	5,759	6,551	1.0 (ref)
AT			1	3,064	3,576	0.97 (0.91 – 1.03)
AA			2	447	491	1.03 (0.90 – 1.18)	0.48
Additive (per allele)						0.99 (0.94 – 1.04)	0.65	0.84
rs10741657	CYP2R1	0.61
AA			0	1,301	1,486	1.0 (ref)
AG			1	4,041	4,766	0.96 (0.88 – 1.05)
GG			2	3,276	3,708	1.00 (0.91 – 1.09)	0.41
Additive (per allele)						1.01 (0.97 – 1.05)	0.72	0.62
rs12785878	DHCR7	0.27
TT			0	4,935	5,674	1.0 (ref)
GT			1	3,620	4,052	1.03 (0.97 – 1.09)
GG			2	669	834	0.92 (0.83 – 1.03)	0.16
Additive (per allele)						0.99 (0.95 – 1.03)	0.60	0.13

^*Adjusted for age at baseline (continuous) and study cohort.

^†For categorical analyses of genotype, the p-value is a 2 degree of freedom test comparing a model containing indicator variables for genotype and covariates with a model containing only the covariates. For the per allele analyses, the p-value is a 1 degree of freedom test comparing a model containing the number of alleles and covariates to a model containing only the covariates.

^§The p-value for heterogeneity across cohorts is based on the test for interaction between cohort and the additive.