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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Immunobiology. 2014 Nov 3;220(4):476–482. doi: 10.1016/j.imbio.2014.10.026

Figure 2.

Figure 2

Cp40 prevents hemodialysis-induced complement activation. (A) Hemodialysis was performed in cynomolgus monkeys for a period of four hours and blood samples were collected prior to, during, and after blood circulation as indicated. Cp40 was injected as an i.v. bolus of 2 mg/kg followed by an i.v. infusion of 4 μg/kg/min. (B) Blood samples were collected from a monkey that was untreated (black line) or treated with Cp40 (gray line) and the activation of complement C3 was measured in plasma samples by ELISA, represented as optical density (O.D.) values. The figure depicts data from blood samples collected from the inflow sampler (Fig. 1A). Similar results were obtained with samples collected from the outflow sampler. (C) Levels of Cp40 were measured by mass spectrometry in the plasma of a monkey treated with Cp40. Samples were collected from both samplers as indicated in Fig. 1A.