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. 2015 Mar;5(3):a018580. doi: 10.1101/cshperspect.a018580

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Figure 2. — Pathology in adult fish compared with human granulomas. Zebrafish granulomas caused by M. marinum show great similarities with human granulomas formed after infection with M. tuberculosis. Panels represent nonnecrotic early granuloma in human (A) and zebrafish (B) and granulomas with a necrotic center in human (C) and zebrafish (D). Human granulomas obtained from a neuropathology study in our Department of Pediatric Infectious Diseases and Immunology (D Zaharie, S Roest, M van der Kulp, AM van Furth, pers. comm.).