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Choreography of homologous recombination (HR) foci in yeast and human cells. Order of recruitment of double-strand break (DSB) repair proteins. Nucleation of proteins at foci start at the upper left. Solid black lines represent absolute requirements (see text). Gray dotted lines represent interactions with specific DNA substrates. Arrows indicate protein–protein interactions, modifying functions, and/or feedback loops. Mammalian homologs are indicated in blue.
