Table 1.
Evolutionary conservation of homologous recombination proteins between Saccharomyces cerevisiae and Homo sapiens
| Functional class | S. cerevisiae | H. sapiens |
|---|---|---|
| End resection | Mre11-Rad50-Xrs2 | MRE11-RAD50-NBS1 |
| Sae2 | CtIP | |
| Exo1 | EXO1 | |
| Dna2-Sgs1-Top3-Rmi1 | DNA2-BLM-TOP3α-RMI1-RMI2 | |
| Adaptors | Rad9 | 53BP1, MDC1 |
| – | BRCA1 | |
| Checkpoint signaling | Tel1 | ATM |
| Mec1-Ddc2 | ATR-ATRIP | |
| Rad53 | CHK2 | |
| Rad24-RFC | RAD17-RFC | |
| Ddc1-Mec3-Rad17 | RAD9-HUS1-RAD1 | |
| Dpb11 | TOPBP1 | |
| Single-stranded DNA binding | Rfa1-Rfa2-Rfa3 | RPA1-RPA2-RPA3 |
| Single-strand annealing | Rad52 | RAD52 |
| Rad59 | – | |
| Mediators | – | BRCA2-PALB2 |
| Rad52 | – | |
| Strand exchange | Rad51 | RAD51 |
| Rad54 | RAD54A, RAD54B | |
| Rdh54 | – | |
| Rad51 paralogs | Rad55-Rad57 | RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 |
| Psy3-Csm2-Shu1-Shu2 | RAD51D-XRCC2-SWS1 | |
| Antirecombinases | Srs2 | FBH1, PARI |
| Mph1 | FANCM | |
| – | RTEL | |
| Resolvases and nucleases | Mus81-Mms4 | MUS81-EME1 |
| Slx1-Slx4 | SLX1-SLX4 | |
| Yen1 | GEN1 | |
| Rad1-Rad10 | XPF-ERCC1 | |
| Dissolution | Sgs1-Top3-Rmi1 | BLM-TOP3α-RMI1-RMI2 |