Table 1.
Respiratory chain enzyme activities in heart, skeletal muscle, and liver tissues
| HEART: | Activity (controls) | SD | Ratio /CS | SD | Ratio/complex II | SD |
|---|---|---|---|---|---|---|
| Complex I | 2.4 (139.9–335.8) | −14.3* | 2 (140–377) | −14.6* | 8 (517–1069) | −16.4* |
| Complex II | 316.8 (175.7–392.8) | +0.5 | 315 (227–357) | +0.9 | NA | NA |
| Complex III | 4.3 (15.5–189.6) | −3.0* | 4 (12–174) | −2.6* | 13 (43–566) | −2.7* |
| Complex II-III | 69.2 (175.3–570.7) | −3.1* | 69 (185–464) | −4.1* | 218 (714–1620) | −4.5* |
| Complex IV | 1.6 (12.0–27.5) | −8.0* | 2 (12–32) | −8.2* | 5 (42–101) | −8.7* |
| Citrate synthase | 1004.7 (492.8–1451.9) | +0.1 | NA | NA | NA | NA |
| MUSCLE: | ||||||
| Complex I | 3.0 (23.6–74.8) | −7.5* | 3 (98–271) | −9.7* | 26 (285–767) | −9.4* |
| Complex II | 115.2 (49.0–133.4) | +0.9 | 112 (251–573) | −2.3* | NA | NA |
| Complex III | 2.5 (5.7–31.4) | −2.7 | 2 (19–172) | −3.0* | 22 (45–369) | −2.8* |
| Complex II-III | 17.4 (34.2–107.6) | −3.3 | 17 (172–472) | −0.5 | 151 (549–1226) | −5.1* |
| Complex IV | 0.3 (1.1–3.8) | −4.9 | 0 (4–23) | −4.3* | 3 (11–68) | −4.6* |
| Citrate synthase | 1024.5 (159.8–353.3) | +5.3* | NA | NA | NA | NA |
| LIVER: | ||||||
| Complex I | 9.3 (14.4–56.0) | −2.5* | 8 (162–730) | −4.2* | 19 (68–252) | −3.2* |
| Complex II | 492.6 (174.7–309.8) | +3.1* | 399 (2304–3311) | −8.5* | NA | NA |
| Complex III | 13.2 (13.8–27.6) | −0.7 | 11 (128–315) | −3.1* | 27 (50–118) | −1.5 |
| Complex II-III | 130.5 (10.8–107.3) | +1.4 | 106 (138–1062) | −1.4 | 265 (62–383) | +0.6 |
| Complex IV | 1.3 (0.5–3.2) | −0.3 | 1 (6–35) | −0.5 | 3 (3–13) | −0.3 |
| Citrate synthase | 1235.7 (59.5–109.3) | +9.5* | NA | NA | NA | NA |
CS, citrate synthase; NA, not applicable; SD, standard deviation
SD represents how many SD the activity or ratio is above or below the mean established in tissues of control subjects.
*
SD of >2 is considered significant