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. 2015 Feb 11;17(1):28. doi: 10.1186/s13075-015-0541-5

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© Lee et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Phase 2 construct morphology, histological analysis, and cell diameter quantification. Phase 2 constructs exhibited no abnormalities and were hyaline-like in appearance. Notably, T3 treatment produced neocartilage with pronounced curvature, suggestive of tissue prestress (A). Picrosirius red and Safranin-O dyes demonstrated robust deposition of collagen and GAG, respectively, in all constructs (B). T3-treated groups possessed more GAG staining than non-T3 treated groups. T3 elicited an increase in cell diameter (C), as measured for cryoembedded, formalin-fixed samples. Groups not connected by the same letter are statistically significant. Data are represented as mean ± standard deviation. GAG, glycosaminoglycan; T3, tri-iodothyronine.