Table 1.
Effect of ZO-ActFr or MCP on cisplatin induced R + V and jerking during a 24 h observation period
| Drug treatment | Dose and route | Pigeons n/ vomited | R + V Mean ± sem | Latency (min) Mean ± sem | Jerks Mean ± sem | Wt loss (%)Mean ± sem |
|---|---|---|---|---|---|---|
| Saline + Cisplatin | 02 ml/kg i.m. + 07 mg/kg i.v. | 6/6 | 43 ± 4.3 | 68 ± 3.7 | 407 ± 64 | 16.6 ± 1.8 |
| MCP + Cisplatin | 30 mg/kg i.m. + 07 mg/kg i.v. | 8/8 | 22 ± 4.3* | 230 ± 84** | 447 ± 103 | 11.5 ± 1.5 |
| ZO-ActFr + Cisplatin | 25 mg/kg i.m. + 07 mg/kg i.v. | 7/7 | 24 ± 4.1 | 124 ± 21 | 246 ± 92 | 8.1 ± 1.0* |
| 50 mg/kg i.m. + 07 mg/kg i.v. | 7/7 | 18 ± 4.2* | 77 ± 15 | 376 ± 97 | 11.3 ± 2.3 | |
| 100 mg/kg i.m. + 07 mg/kg i.v. | 8/8 | 31 ± 5.6 | 85 ± 15 | 569 ± 125 | 9.1 ± 1.6 |
*p < 0.05, **p < 0.01 (ANOVA followed by Tukey post hoc test).