Table 2.

Effect of ZO-ActFr (50 mg/kg) administered 30 minutes before saline administration, on the basal level of neurotransmitters and their metabolites (ng/mg tissue wet weight) in the brain areas and intestine in pigeons at t = 3 hr (n = 6–8)

Treatment	NA	DOPAC	DA	5HIAA	HVA	5HT
Area postrema
Saline	0.610 ± 0.014	0.382 ± 0.111	0.590 ± 0.146	0.158 ± 0.036	0.913 ± 0.095	0.062 ± 0.034
MCP 30 mg	0.023 ± 0.005	0.017 ± 0.006	0.025 ± 0.012	0.005 ± 0.001*	0.121 ± 0.063*	0.023 ± 0.001
ZO-ActFr 50 mg	0.372 ± 0.036	0.122 ± 0.047	0.191 ± 0.037	0.039 ± 0.006	0.874 ± 0.204	0.045 ± 0.008
Brain stem
Saline	0.094 ± 0.022	0.060 ± 0.020	0.175 ± 0.078	0.060 ± 0.021	0.060 ± 0.016	0.010 ± 0.003
MCP 30 mg	0.119 ± 0.033	0.027 ± 0.006	0.044 ± 0.012	0.007 ± 0.001***	0.066 ± 0.031	0.019 ± 0.002
ZO-ActFr 50 mg	0.056 ± 0.055	0.128 ± 0.127	0.082 ± 0.054	0.011 ± 0.001*	0.088 ± 0.021	0.020 ± 0.001
Intestine
Saline	0.194 ± 0.059	0.067 ± 0.020	0.090 ± 0.064	0.076 ± 0.058	0.056 ± 0.025	0.049 ± 0.016
MCP 30 mg	0.138 ± 0.039	0.054 ± 0.025	0.059 ± 0.018	0.097 ± 0.022	0.198 ± 0.102	0.062 ± 0.013
ZO-ActFr 50 mg	0.334 ± 0.131	0.037 ± 0.028	0.356 ± 0.113	0.050 ± 0.008	0.231 ± 0.110	0.103 ± 0.015

Standard MCP is also shown.

Values significantly different compared to basal level (saline) are indicated as *p < 0.05, ***p < 0.001 (ANOVA followed by Tukey post hoc analysis).