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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Am J Ophthalmol. 2014 Oct 2;159(1):124–30.e1. doi: 10.1016/j.ajo.2014.09.044

FIGURE 1.

FIGURE 1

Assessment of TBK1 gene dosage by quantitative polymerase chain reaction in Australian patients with primary open-angle glaucoma. The x-axis shows the number of copies of the TBK1 gene that were detected in each subject. The normal dosage of 2 copies of TBK1 was detected in the control (Subject 1466). Three probands from unrelated pedigrees (AG624, AG724, and GFMC524) were found to have 1 extra copy of TBK1 (3 total copies) while the proband AG604 was found to have 2 extra copies of TBK1 (4 total copies). AG, advanced glaucoma; GFMC, nonadvanced glaucoma; the positive control was from a normal-tension glaucoma patient previously reported to carry a TBK1 gene duplication.16