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. 2015 Mar 11;4(3):e15. doi: 10.1038/emi.2015.15

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PCV2 reinfection caused reverse CD4 coreceptor-TCR dichotomy in latently infected pigs. (A) Contour plot of CD4 versus CD8 coreceptor-expressing control thymocytes with gated cell populations (percentage numbers of total thymocytes). (B, C) PCV2 productive infections cause thymic reverse CD4 coreceptor-TCR dichotomy on CD4⁺CD8^interm (interm: intermediate) cells and CD4SPs. (B) Histogram comparisons of CD8 and CD4 coreceptor and TCR expression on PCV2a/b versus control thymocytes by flow cytometry. CD4⁺CD8^interm and CD4SPs gated for TCR^high expression (gate: G). (C) PCV2 reinfection caused TCR downregulation on CD4⁺CD8^interm and CD4SPs. Statistical TCR downregulation analysis on PCV2a/b (n=9) versus control (n=3) or CysA (n=4) or ToPMWS (n=3); pigs per group (n); *P<0.02, Kruskal–Wallis rank sum test; PMWS (n=2).