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. 2015 Feb 13;17(1):32. doi: 10.1186/s13075-015-0548-y

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© Andersson et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Absolute numbers of lymph node CD4 ⁺ cells and Th17 cells after estrogen treatment in early collagen-induced arthritis. DBA/1 mice were ovariectomized, subjected to collagen-induced arthritis (CIA) and treated with 17β-estradiol (E2; 0.83 μg/day) or placebo. (A,B) Absolute number of T helper 17 (Th17) cells (A) and CD4⁺ cells (B) in one subiliac lymph node (LN) of CIA mice (day 14, n = 10 or 11 mice/group), obtained by multiplying cell population frequencies obtained by fluorescence-activated cell sorting by total LN cellularity. To improve normal distribution of data, some data were log-transformed prior to statistical analysis (A). Arithmetic mean ± SEM is shown in all graphs. Student’s t-test (B) or Welch’s t-test (A) was used (*P <0.05).