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. 2015 Feb 24;34(1):20. doi: 10.1186/s13046-015-0138-5

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© Chen et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Inactivate of AKT/GSK3β and reduce translocation of β-catenin in IGFBP-7 overexpression A253-5 cells. (A) Western blot analyzed the phosphorylation of AKT (Thr 308) and GSK3β (Ser 9). (B) Western blot using protein from nuclear fraction is analyzed. C: A253-5, Mock: A253-5 transfected with pEGFP-N1, IGFBP7: Transient IGFBP-7 expression A253-5 cells, IGFBP7 + NCsi: Transient IGFBP-7 expression A253-5 cells transfected with negative control siRNA, IGFBP7 + siRNA: Transient IGFBP-7 expression A253-5 cells transfected with siRNA against IGFBP7. *** indicated p < 0.001 compared with A253-5 Mock cells. # indicated p < 0.01 compared with IGFBP7 + NCsi.