Table 1.

Imaging biomarker definitions.

Variable	Description
Volume	Gross tumor volume (cm3)
SUVmean	Mean SUV in the GTV
SUVmax	Maximum voxel SUV in the GTV
$R_{\text{SUVmean}}^{\text{FLT}}$	Fractional change in FLT SUVmean from pretreatment to midtreatment
$R_{\text{SUV}max}^{\text{FLT}}$	Fractional change in FLT SUVmax from pretreatment to midtreatment
$R_{\text{SUVmean}}^{\text{Cu}-\text{ATSM}}$	Fractional change in Cu-ATSM SUVmean from pretreatment to midtreatment
$R_{\text{SUV}max}^{\text{Cu}-\text{ATSm}}$	Fractional change in Cu-ATSM SUVmax from pretreatment to midtreatment
ρFDG,FLT	Spatial (voxel) correlation between pretreatment FDG and FLT uptake distributions
ρFDG,Cu-ATSM	Spatial (voxel) correlation between pretreatment FDG and Cu-ATSM uptake distributions
ρ FLT,Cu-ATSM	Spatial (voxel) correlation between pretreatment FLT and Cu-ATSM uptake distributions
${\rho }_{\text{pre},\text{mid}}^{\text{FLT}}$	Spatial (voxel) correlation between pretreatment and midtreatment FLT uptake distributions
${\rho }_{\text{pre},\text{mid}}^{\text{Cu}-\text{ATSM}}$	Spatial (voxel) correlation between pretreatment and midtreatment Cu-ATSM uptake distributions

Abbreviations: SUV = standardized uptake value; GTV = gross tumor volume; FLT = 3′-deoxy-3′-¹⁸F-fluorothymidine; Cu-ATSM = copper(II)-diacetyl-bis(N4-methylthiosemicarbazone); FDG = 2-deoxy-2-[¹⁸F]fluoro-D-glucose