. 2014 Dec 31;2014(4):360–366. doi: 10.5339/gcsp.2014.49

Table 2.

PROFICIO program

Study	Aim
GAUSS-2 ¹⁴ , GAUSS-3	Statin intolerant patients
RUTHERFORD-2 ¹⁵	Heterozygous Familial hypercholesterolemia
MENDEL-2	Evolocumab stand-alone monotherapy
TESLA Part B ¹⁶	Homozygous familial hypercholesterolemia
LAPLACE-2 ¹⁷ , YUKAWA-2	Combination therapy with statins
DESCARTES ¹⁸ , OSLER-2	Long term (52 weeks) therapy
TAUSSIG	Long term therapy in familial hypercholesterolemia
FOURIER	Secondary prevention of CV events
GLAGOV	Plaque regression measured by intravascular ultrasound

PROFRICO (Latin word means: to advance or to make progress)