Table 1.

Mutations in cardiac ion channel genes and clinical consequences.

Current	Channel	Gene	Disease	Number of mutations
I Na	Nav1.5	SCN5A	LQT3	87
			BrS	374
			CCD	21
			SSS	9
I to	Kv4.2/4.3	KCND2/3	BrS	2
I Ca	Cav1.2	CACNA1C	LQT8	2
			SQTS/BrS	10
			ERS	1
		CACNB2	SQTS/BrS	6
			IVF/ERS	3
		CACNA2D1	BrS	2
			ERV	1
I Ks	KvLQT1	KCNQ1	LQT1	246
			SQTS	2
			FAF	3
	minK	KCNE1	LQT5	69
			FAF	16
I Kr	hERG	KCNH2	LQT2	297
			SQTS	1
			BrS	2
	MiRPI	KCNE2	LQT6	16
I K1	Kir2.1	KCNJ2	LQT7	29
			SQTS	2
			FAF	2

Abbreviations: LQT – long QT syndrome, BrS – Brugada syndrome, CCD – cardiac conduction disease, SSS – sick sinus syndrome, SQTS – short QT syndrome, FAF – familiar atrial fibrillation, ERS – early repolarization syndrome, IVF – idiopathic ventricular fibrillation. Helpful databases were PubMed/Medline, http://www.fsm.it/cardmoc/ and http://www.qtsyndrome.ch/.