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. 2015 Feb 18;17(1):33. doi: 10.1186/s13075-015-0544-2

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© Peffers et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Top-scoring networks derived from the 325 genes differentially expressed in ageing. (A) Ingenuity pathway analysis (IPA) identified from cellular function and maintenance as the principal associated network functions with scores of 43. (B) The second top-scoring network was a cellular growth and proliferation, with scores of 32. (C) IPA identified cell cycle and skeletal and muscular system development function with a score of 32. (D) The fourth top-scoring network was cellular development, with a score of 28. Figures are graphical representations between molecules identified in our data in their respective networks. Green nodes indicate upregulated gene expression in older tendon; red nodes indicate downregulated gene expression in older tendon. Intensity of colour is related to higher fold change. The key to the main features in the networks is shown.