Table 3.

The literature suggested functions of the 12 miRNAs in HCC.

miRNA	Function
miR-10a	Is involved in metastatic process of HCC.
miR-23a/24/27a	This cluster can promote hepatic metastasis.
miR-26a	Acts as a tumor suppressor in liver; patients with lower miR-26 level have shorter overall survival.
miR-30c/30e	miR-30 family expression is significantly expressed in HCC patients with metastasis.
miR-31	Is significantly expressed in HCC patients and its expression is correlated with liver cirrhosis.
miR-106b	Plays a critical role in development of HCC metastasis.
miR-133b	Plays a role in the development of HCC by regulating CD133(+) liver tumor initiating cells.
miR-199a-3p	Is associated with progression of liver fibrosis and can influence the doxorubicin sensitivity of human hepatocarcinoma cells.
miR-200b	Can mediate hepatocellular carcinoma cell migration, closely associated with progression of liver fibrosis.