Fig 1. Frequency of FLG mutations in fathers, mothers, individuals with atopic dermatitis and controls.

Allele and genotype frequencies of the combined FLG-mutations in fathers and mothers were calculated using all available parents. AD refers to the frequency in the AD-affected children including the families and the unrelated AD-cases (available only in the Central European study). Frequency in controls corresponds to population-based individuals with unknown disease status. Results of the Central and Northern European populations are shown in panels A and B, respectively.