Table 5. Parent-of-origin-analysis analysis stratified by maternal specific sensitization.

Children Genotype model (CG)
Group	n a	R1 (CI)	R2 (CI)	S1 (CI)	P null b	P MCG vs CG c
+Mat_sens	253	1.37 (0.97–1.94)	2.98 (1.19–7.45)	-	0.03	-
−Mat_sens	311	2.30 (1.64–3.22)	7.19 (3.77–13.7)	-	9.9 x 10−11	-
Maternal Child Genotype model (MCG)
Group	n a	R1 (CI)	R2 (CI)	S1 (CI)	P null b	P MCG vs CG c
+Mat_sens	253	1.37 (0.97–1.93)	2.97 (1.19–7.43)	1.63 (1.15–2.31)	0.002	0.005
−Mat_sens	311	2.30 (1.64–3.22)	7.19 (3.77–13.69)	1.18 (0.86–1.61)	3.2 x10−10	0.30

^a Number of families.

^b P value for the comparison with the null model with no effects.

^c P value for the comparison with the Child Genotype model.

CI indicates 95% confidence interval. All results correspond to the combined FLG mutations. Note that all unrelated cases and population-based controls were excluded from this analysis due to missing maternal sensitization data.