Table 6. TDT analysis stratified by maternal specific sensitization.
Transmission Disequilibrium Test (TDT) | Allelic test in children d | |||||
---|---|---|---|---|---|---|
Group | n a | T / U b | OR c | P | Mut freq | OR (P) |
+Mat_sens | 253 | 97 / 65 | 1.49 | 0.04 | 0.11 | 1 |
−Mat_sens | 311 | 169 / 68 | 2.49 | 5.3 x10−8 | 0.16 | 1.48 (0.005) |
a Number of families.
b Number of transmitted (T) and un-transmitted (U) alleles. Allele counts are referred to the combined FLG mutations.
c Odds ratio calculated as the ratio of transmitted versus un-transmitted alleles.
d Comparison of allelic frequency between AD-affected children of the −Mat_sens versus the +Mat_sens families.