Figure 3. Antho 50 induces caspase 3 activation and UHRF1 down-regulation independently of p53 and p73.
B CLL cells were incubated with Antho 50 at 75 μg/mL for the indicated times and thereafter the expression of the p53, p73, cleaved caspase 3 and UHRF1 was studied using Western blot. The control (Ctr) represents untreated cells harvested at 6 h. The data are representative of cells from six CLL patients. Cleaved caspase 3 and UHRF1 expression levels were analyzed by densitometry and represented as percentage compared with control.