Table 2.
Skp2 protein expression in 138 human gastric cancers
| Clinicopathological feature | Specimens |
Skp2 labeling frequency (%) |
||
| (n) | Mean±SE | rho | P | |
| Patients | 138 | 36.32±1.22 | ||
| Age (yr) | 138 | 58.50 | 0.190 | 0.833 |
| ＜60 | 66 | 34.25±3.58 | ||
| ≥60 | 72 | 34.41±2.63 | ||
| Gender | 0.119 | 0.179 | ||
| Females | 27 | 24.96±5.21 | ||
| Males | 111 | 32.90±2.37 | ||
| Differentiation grade1 | 0.315 | 0.000 | ||
| Well/Moderate | 63 | 22.41±2.59 | ||
| Poor | 75 | 38.85±3.10 | ||
| Depth of invasion | 0.001 | 0.986 | ||
| Serosal | 24 | 25.84±2.45 | ||
| Outside soft tissue | 114 | 29.25±4.87 | ||
| Vessel invasion2 | 0.303 | 0.000 | ||
| Absent | 120 | 27.89±2.11 | ||
| Present | 18 | 54.39±6.84 | ||
| Lymph node metastasis3 | 0.254 | 0.000 | ||
| Absent | 36 | 27.94±3.38 | ||
| Present | 102 | 37.14±2.69 | ||
| Distant metastasis | 0.091 | 0.307 | ||
| Absent | 26 | 22.77±6.92 | ||
| Present | 12 | 31.79±2.38 | ||
| Clinical stage | 0.069 | 0.440 | ||
| 0 | 0 | |||
| Ia | 0 | |||
| Ib | 3 | 22.78±6.92 | ||
| II | 36 | 29.81±3.14 | ||
| IIIa | 12 | 44.67±6.78 | ||
| IIIb | 66 | 34.50±3.55 | ||
| IV | 9 | 53.00±0.57 |
1, 2, 3Skp2 labeling frequency was positively correlated with differentiated degree (rho = 0.315, P = 0.000), vessel invasion (rho = 0.303, P = 0.000), and lymph node metastasis (rho = 0.254, P = 0.000) in gastric carcinoma, respectively. 4Because clinical staging could not be performed due to the lack of accurate records about lymph node in operation, data of 12 cases were cancelled in statistical analysis.