Table 4.
The number of WRS-induced gastric lesions and accompanying changes in the GBF in rats treated with vehicle and GSE (32 mg/kg i.g.) without or with capsaicin denervation. Means±SE of 6–8 rats
| Type of test | Mean lesion number | GBF (% control) |
| Without capsaicin denervation | ||
| Vehicle | 18 ± 3 | 67 ± 4 |
| GSE (32 mg/kg ig) | 8 ± 1.5a | 78 ± 3a |
| With capsaicin denervation | ||
| Vehicle | 28 ± 4b | 54 ± 3b |
| GSE (32 mg/kg ig) | 16 ± 3b | 64 ± 4b |
| CGRP (10 μg/kg sc) | ||
| +GSE (32 mg/kg ig) | 9 ± 1.3c | 74 ± 3c |
a
P < 0.05 vs vehicle,
c
P < 0.05 vs corresponding values obtained in animals without capsaicin denervation, eP < 0.05 vs corresponding values obtained in animals with capsaicin denervation without CGRP treatment.