Table 2.
Main characteristics of MTHFR A1298C polymorphism studies included in the meta-analysis
| Case | Control | Genotype (case/control) | Allele (case/control) | HWE | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Firstauthor | Year | Country | Ethnicity | Source ofcontrols | n | n | AA | AC | CC | A n (%) | C n (%) | (P)## |
| Van Rooijet al. (7) | 2003 | Netherlands | White | PB | 125 | 159 | 57/76 | 52/67 | 16/16 | 166(66)/219(69)# | 84(34)/99(31)# | 0.83 |
| Shotelersuket al. (33) | 2003 | Thailand | Asian | PB | 67 | 202 | 30/108 | 33/80 | 4/14 | 93(69)/296(73) | 41(31)/108(27) | 0.88 |
| Pezzettiet al. (34) | 2004 | Italy | White | HB | 104 | 254 | 57/121 | 36/130 | 11/38 | 150(72)/372(64) | 58(28)/206(36) | 0.74 |
| Mills et al.(37) | 2008 | Ireland | White | HB | 366 | 1050 | 179/519 | 164/439 | 23/92 | 522(71)/1477(70)# | 210(29)/623(30)# | 0.95 |
| Ali et al.(19) | 2009 | India | Asian | PB | 116 | 214 | 64/99 | 47/97 | 5/18 | 175(75)/295(69) | 57(25)/133(31) | 0.4 |
| Sozen et al.(23) | 2009 | Venezuela | Mixed | PB | 168 | 138 | 119/101 | 47 /33 | 2 /4 | 285(85)/235(85) | 51(15)/41(15) | 0.52 |
| Tolarovaet al. (48) | 1998 | Argentina | White | PB | 86 | 78 | 56/50 | 27/25 | 3/3 | 114(78)/125(80)# | 33(22)/31(20)# | 0.95 |
PB; Population based, HB; Hospital based, HWE; Hardye Weinberg equilibrium, NA; Not available, #; Numbers calculated by the distribution of genotype and ##; P value of HWE were calculated by original data.