Table 3.
Results of Meta-analysis of MTHFR C677T polymorphism for studies on NSCL/P
| Groups | Studynumber | Sample size(case/control) | TT versus CC | CT versus CC | CT+TT versus CC (dominant) | TT versus CT+CC (recessive) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR(95% CI) | I2(%) | Ph | OR (95% CI) | I2(%) | Ph | OR (95% CI) | I2(%) | Ph | OR(95% CI) | I2(%) | Ph | ||||
| Overall | 15 | 2442/4655 | 1.251(1.047,1.494) | 34.4 | 0.076 | 0.982(0.824,1.171) | 50.5 | 0.008# | 1.048(0.884, 1.244) | 53.8 | 0.004# | 1.325(1.124, 1.562) | 31.2 | 0.102 | |
| Ethnicity | |||||||||||||||
| Asians | 4 | 369/582 | 1.565(0.887,2.761) | 71.1 | 0.016# | 1.378(0.796, 2.385) | 62.2 | 0.047# | 1.505(0.849, 2.667) | 67.5 | 0.026# | 1.726(1.090, 2.733) | 65.5 | 0.034# | |
| Whites | 8* | 1269/2853 | 1.243(0.992,1.558) | 13.2 | 0.327 | 0.920(0.794, 1.066) | 0.0 | 0.704 | 0.973(0.847, 1.118) | 0 | 0.712 | 1.308(1.059, 1.617) | 27.7 | 0.207 | |
| Others | 6* | 804/1220 | 1.172(0.839,1.639) | 26.1 | 0.238 | 0.969(0.666, 1.410) | 66.6 | 0.010# | 1.010(0.702, 1.452) | 68 | 0.008# | 1.194(0.865, 1.648) | 1.9 | 0.404 | |
| Source of control | |||||||||||||||
| HB | 8 | 1702/3716 | 1.248(1.024,1.520) | 56.9 | 0.01# | 0.957(0.821, 1.114) | 17.3 | 0.279 | 1.026(0.861, 1.223) | 38.4 | 0.093 | 1.324(1.104, 1.588) | 55.3 | 0.013# | |
| PB | 7 | 740/939 | 1.262(0.842,1.892) | 0 | 0.842 | 1.052(0.670, 1.650) | 73.0 | 0.001# | 1.074 (0.723,1.596) | 70.7 | 0.002# | 1.329(0.899, 1.965) | 0 | 0.885 | |
*; In Gaspar et al. (11) study, there have the data not only of whites but also of others, I2; Quantification of the heterogeneity, Ph; P values for heterogeneity from Q test, #; Random-effect model was used when p value for heterogeneity test <0.05, otherwise, fix-effect model was used, PB; Population based and HB; Hospital based.