Table 4.
Results of Meta-analysis of MTHFR A1298C polymorphism for studies on NSCL/P
| Groups | Studynumber | Sample size(case/control) | TT versus CC | CT versus CC | CT+TT versus CC (dominant) | TT versus CT+CC (recessive) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR(95% CI) | I2(%) | Ph | OR (95% CI) | I2(%) | Ph | OR (95% CI) | I2(%) | Ph | OR(95% CI) | I2(%) | Ph | ||||
| Overall | 7 | 1032/2095 | 0.744 | 0 | 0.64 | 0.991 | 32 | 0.184 | 0.952 | 33.5 | 0.172 | 0.766 | 0 | 0.738 | |
| (0.545,1.016) | (0.844,1.164) | (0.816,1.111) | (0.567,1.036) | ||||||||||||
| Ethnicity | |||||||||||||||
| Asians | 2 | 183/416 | 0.611 | 15.7 | 0.276 | 0.986 | 69.5 | 0.070 | 0.929 | 73.1 | 0.054 | 0.618 | 0 | 0.479 | |
| (0.281,1.329) | (0.687,1.413) | (0.655,1.316) | (0.289,1.321) | ||||||||||||
| Whites | 4 | 681/1541 | 0.794 | 0 | 0.505 | 0.966 | 39.1 | 0.177 | 0.938 | 38 | 0.184 | 0.822 | 0 | 0.565 | |
| (0.561,1.125) | (0.797,1.170) | (0.780,1.126) | (0.588,1.150) | ||||||||||||
| Others | 1 | 168/138 | 0.424 | - | - | 1.209 | - | - | 1.124 | - | - | 0.404 | - | - | |
| (0.076,2.365) | (0.720,2.029) | (0.680,1.858) | (0.073,2.237) | ||||||||||||
| Source | |||||||||||||||
| of control | |||||||||||||||
| HB | 2 | 470/1304 | 0.690 | 0 | 0.715 | 0.828 | 79.3 | 0.028# | 0.807 | 76.9 | 0.037# | 0.722 | 0 | 0.797 | |
| (0.459,1.036) | (0.457,1.501) | (0.476,1.366) | (0.487,1.071) | ||||||||||||
| PB | 5 | 562/791 | 0.834 | 0 | 0.448 | 1.038 | 0 | 0.444 | 1.008 | 5.9 | 0.373 | 0.839 | 0 | 0.526 | |
| (0.513,1.358) | (0.818,1.316) | (0.802,1.266) | (0.523,1.345) | ||||||||||||
I2; Quantification of the heterogeneity, Ph; P values for heterogeneity from Q test, #; Random-effect model was used when p value for heterogeneity test <0.05, otherwise, fix-effect model was used, " -"; no I2 and Ph because only 1 study in this subgroup, PB; Population based and HB; Hospital based.