Diagrammatic representation shows the sources of H2S and moreover anabolism and catabolism of H2S. The usual sources of H2S are blood lung, kidney, heart, and brain. Free H2S gets converted into sulfate and thiosulfate through mitochondrial oxidation and sulfomethane via methylation which becomes a source of H2S. Diagram also depicts the synthesis, storage, and function of H2S in neuronal synapse. These free H2S involved in NMDA receptor signaling, Na+ K+ ATPase signaling, and glutathione formation maintains and regulates neuronal function.