Figure 3.
Cartoon represents the structure of tripartite synapse (presynapse, postsynapse, and astrocyte). In astrocyte, H2S interacts with H2S and slow down the excessive glutamate and calcium ion release from astrocyte. On the other hand, in pathological condition H2S moderates the calcium ion influx through NMDA receptor in postsynapse and prevents from excitotoxic cell death. Neuronal synapses showing the presence of H2S in presynapse and postsynapse. Moreover, it also represents how H2S interacts with NMDA receptors; actually, H2S modulates the NMDA receptor and controls synapse function properly. Apart from that H2S also associated with glutathione production in cells which acts as cellular antioxidant.