Figure 4.
Flow diagram indicates the interaction and regulation of CBS enzyme with the help of CaMKII, calcium ion, S-adenosyl methionine, and pyridoxal-5′-phosphate. In other ways, CaMKII also potentiate the NMDA receptor via cAMP pathways. Further, H2S produced from different sources with the help of CBS enzyme interacts with NMDA receptor and modulates their function and thereby maintains the synaptic plasticity. P-5P, pyridoxal-5′-phosphate; cAMP, cyclic adenosine monophosphate; CamKIIα, calmodulin kinase II alfa; SAM, S-adenosyl methionine; NMDA, N-methyl-d-aspartate.