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. 2015 Mar 8;12:47. doi: 10.1186/s12974-015-0261-4

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© Dai et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The effect of central infusion of AT2-R antagonist PD123,319 on DOCA/salt-induced hypertension in male rats. Daily mean arterial pressures (MAP) (A) and heart rate (HR) (B) before and during DOCA/salt treatments in male rats with or without central infusions of PD123,319. Average changes in MAP and HR induced by DOCA/salt treatment in all groups (C,D). *P < 0.05 compared to females with central infusion of PD123,319 alone. DOCA, deoxycorticosterone acetate; icv, intracerebroventricular.