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. 2015 Mar 11;9:73. doi: 10.3389/fncel.2015.00073

Figure 2.

Figure 2

Chemical inhibition of MMP-9 with highly specific inhibitor S24994 results in destabilization of LTP in the central but not in the lateral amygdala. (A) MMP-9 inhibitor S24994 (100 nM) administrated 15 min before LTP induction did not affect fEPSP in the EC–LA amygdala pathway (open circles, n = 4) in comparison with control, untreated slices (filled circles, n = 5). (B) MMP-9 inhibitor S24994 (100 nM) administrated 15 min before LTP induction destabilized fEPSP in the BA-CeAm pathway 30 min after its induction (open circles, n = 4), whereas fEPSP evoked in control slices was unaffected (filled circles, n = 5). Black arrows mark the time of application of TBS stimulation. Error bars represent SEM. Beneath the graphs there are exemplary traces of fEPSP 10 min before (black) and 15 and 90 min after (gray) induction of LTP. Scale bars = 0.2 mV and 5 ms.