Table 1.

Proposed targets, roles in PPHN and potential pharmacologic approaches.

Target	Proposed role in PPHN	Potential pharmacologic approaches
Complex III	Generates ROS in response to stretch, hypoxia	Terpestacin, MitoQ
NFκB	Amplifies gene expression in response to ROS, stretch, hypoxia, inflammation	Pyrrolidine dithiocarbamate, glucocorticoids
HIF	Amplifies gene expression in response to ROS, stretch, hypoxia	Glyceollins
Nox	Generate sustained ROS in response to stretch, hypoxia Dysregulate enzymes important for NO signaling	Pyrazolopyridine derivatives (GKT137831), triazolo pyrimidine derivatives (VAS 2870)
ETAR	Vasoconstriction and vascular smooth muscle growth	Bosentan, Ambrisentan, Macitentin