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. 2015 Mar 11;9:62. doi: 10.3389/fnbeh.2015.00062

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Copyright © 2015 Speranza, Giuliano, Volpicelli, De Stefano, Lombardi, Chambery, Lacivita, Leopoldo, Bellenchi, di Porzio, Crispino and Perrone-Capano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cdc42 signaling pathway is required for neurite elongation induced by 5-HT7R stimulation. (A) Striatal and (B) cortical neurons were treated for 2 h either with the 5-HT7R selective agonist LP-211 (LP, 100 nM), or with the selective Cdc42 inhibitor ZCL (50 μ M), or with a combination of the two. The graphs show the neurite length expressed as percentage of values measured in the corresponding vehicle-treated cultures (CTRL, set to 100%). The bars represent means ± SEM from randomly selected fields for each cell culture condition (n = 6). Asterisk (*): values significantly different from CTRL by One Way ANOVA followed by Dunnett post-hoc test (p < 0.05). Number sign (#): values significantly different from each other by One Way ANOVA followed by Tuckey post-hoc test (p < 0.05).