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Systemic concentration of energy substrates and the hormone insulin at the initial and final time points of the experiment in animals allowed food ad libitum (AL) or exposed to 15% caloric restriction (CR). (A) Blood β-hydroxybutyrate (β-HB) levels (mmol/l). (B) Blood glucose concentrations (mg/dl). (C) Plasma insulin levels (ng/ml). ##p ≤ 0.01 and ###p ≤ 0.001, initial vs. final.
