Table 1.
Commonly studied PLIN1 single-nucleotide polymorphisms (SNPs) and obesity-related phenotypes in humans.
| SNP | Population | Main findings | References |
|---|---|---|---|
| rs2289487 | Spanish (n = 1,589) | Lower obesity, glucose, and related traits in women | Qi et al. (2004)26 |
| rs2289487 | US whites, nested case-control (n = 431 cases, n = 791 controls) | Higher diabetes risk | Qi et al. (2008)47 |
| rs2289487 | US whites (n = 271) Spanish men (n = 88) |
Lower postprandial response | Perez-Martinez et al. (2008)55 |
| rs894160 | Swedish women (n = 117) | Lower adipocyte perilipin, higher lipolysis | Mottagui-Tabar et al. (2003)24 |
| rs894160 | Spanish (n = 1,589) | Lower obesity, glucose, and related traits in women | Qi et al. (2004)26 |
| rs894160 | Singaporean Chinese, Indians, and Malays (n = 4,131) | Higher obesity risk in women | Qi et al. (2005)28 |
| rs894160 | Japanese men (n = 148) | Higher BMI | Sone et al. (2010)29 |
| rs894160 | Spanish women (n = 48) | Resistance to weight loss (energy-restricted intervention) | Corella et al. (2005)36 |
| rs894160 | US Puerto Ricans (n = 920) | Lower obesity traits with high complex carbohydrate intake | Smith et al. (2008)37 |
| rs894160 | Spanish (n = 78) | Resistance to weight loss (energy-restricted intervention), lower lipid oxidation | Ruiz et al. (2011)38 |
| rs894160 | Dutch (n = 188) | Higher weight loss and fat loss (weight-loss intervention) | Soenen et al. (2009)40 |
| rs894160 | Koreans (n = 277) | Higher weight loss, greater FFA change following weight loss | Jang et al. (2006)42 |
| rs894160 | Koreans (n = 160) | Lower weight gain with rosiglitazone (antiglycemic) | Kang et al. (2006)43 |
| rs894160 | US whites, nested case-control (n = 431 cases, n = 791 controls) | Higher diabetes risk | Qi et al. (2008)47 |
| rs894160 | Singaporean Chinese, Malays, and Indians, (n = 1,909 men, n = 2,198 women) | Interaction between saturated-fat-to-carbohydrate ratio and insulin resistance in women | Corella et al. (2006)49 |
| rs894160 | US whites (n = 462 men, n = 508 women) | Interaction between saturated-fat-to-carbohydrate ratio and insulin resistance in women | Smith et al. (2012)50 |
| rs894160 | US whites (n = 271) Spanish men (n = 88) |
Lower postprandial response | Perez-Martinez et al. (2008)55 |
| rs2304795 | US whites (n = 734) | Higher obesity risk in women | Qi et al. (2004)27 |
| rs2304795 | Singaporean Chinese, Indians, and Malays (n = 4,131) | Higher obesity risk in women | Qi et al. (2005)28 |
| rs2304795 | US whites (n = 56 women, n = 46 men) | Lower gains in aerobic capacity; altered glucose and lipid metabolism (response to endurance exercise intervention) | Jenkins et al. (2010)56 |
| rs1052700 | US whites (n = 734) | Higher obesity risk in women | Qi et al. (2004)27 |
| rs1052700 | Singaporean Chinese, Indians, and Malays (n = 4,131) | Lower obesity risk in women | Qi et al. (2005)28 |
| rs1052700 | Brazilian children, aged 7–14 (n = 234) | Higher weight loss (weight-loss intervention), lower insulin | Deram et al. (2008)41 |
| rs1052700 | Koreans (n = 277) | Higher weight loss, greater FFA change following weight loss | Jang et al. (2006)42 |
| rs1052700 | US women with (n = 185) and without (n = 120) polycystic ovarian syndrome | Glucose intolerance | Kawai et al. (2009)46 |
| rs1052700 | Singaporean Chinese, Malays, and Indians, (n = 1,909 men, n = 2,198 women) | Interaction with saturated-fat-to-carbohydrate ratio for insulin resistance | Corella et al. (2006)49 |
| rs1052700 | US whites (n = 56 women, n = 46 men) | Lower gains in aerobic capacity; altered glucose and lipid metabolism (response to endurance exercise intervention) | Jenkins et al. (2010)56 |
Abbreviations: BMI, body mass index; FFA, free fatty acids.