Skip to main content
. Author manuscript; available in PMC: 2015 Nov 3.
Published in final edited form as: Thromb Haemost. 2014 Sep 18;112(5):883–892. doi: 10.1160/TH14-05-0448

Figure 2. APC neuroprotective effects and tPA-induced hemorrhage during murine ischemic stroke.

Figure 2

in vivo neuroprotective effects of recombinant mouse wt-APC in C57Bl6 mice during focal ischemic stroke. APC or vehicle was given 10 min after MCAO. Motor neurological score (A), total brain injury volume (B) and post-ischemic cerebral blood flow (C). Brain hemorrhage mediated by tPA after transient ischemia in mice was determined 24 h after transient MCAO for mice receiving the indicated treatments (D), where the bottom two images show brains for mice receiving either 0.2 mg/kg APC with tPA or 2.0 mg/kg APC at 3h after tPA. Bleeding in the ischemic brain was quantified by hemoglobin after treatment with or without rh-tPA (0.2 mg/kg) and with or without simultaneous infusion or infusion 3 h post-tPA of mouse wt-APC (0–2 mg/kg) (E). Panels A-C are from Cheng et al. Nat Med 2003 (34), panels D–E are from Cheng et al. Nat Med 2006 (38).