Table 1.
Term enrichment among FOXL2 targets in cultured murine primary cells and FOXL2 targets shared with in vivo analysis
| ID | Term | Count | Bonferroni | p-Value | Genes |
|---|---|---|---|---|---|
| GO TERM ENRICHMENT of FOXL2 target genes | |||||
| GO:0007155 | cell adhesion | 34 | 6.10−6 | 3.10−9 | NRP2, CDK5R1, CLSTN2, MYBPC3, LMO7, CLDN11, SOX9, CD24A, CNTNAP5A, TGFB2, WISP2, WISP1, PVRL1, ADAM2, MSLN, ACAN, COL6A2, PSTPIP1, COL6A1, ITGA1, ITGA2, PCDH8, PCDH7, EMILIN2, MCAM, GPR98, PCDH18, AMIGO2, ITGA9, OMD, FREM2, ITGA7, VCAN, BMPR1B |
| GO:0022610 | biological adhesion | 34 | 6.10−6 | 3.10−9 | NRP2, CDK5R1, CLSTN2, MYBPC3, LMO7, CLDN11, SOX9, CD24A, CNTNAP5A, TGFB2, WISP2, WISP1, PVRL1, ADAM2, MSLN, ACAN, COL6A2, PSTPIP1, COL6A1, ITGA1, ITGA2, PCDH8, PCDH7, EMILIN2, MCAM, GPR98, PCDH18, AMIGO2, ITGA9, OMD, FREM2, ITGA7, VCAN, BMPR1B |
| GO:0010817 | regulation of hormone levels | 16 | 2.10−5 | 1.10−8 | HSD17B1, EXOC3L, ADH7, VGF, IRS1, ALDH1A2, ACE, RDH10, DIO2, AKR1C18, CHST8, HSD11B2, BMPR1B, PCSK5, SMPD3, CYP19A1 |
| GO:0042127 | regulation of cell proliferation | 29 | 1.10−3 | 7.10−7 | FGFR2, FGF18, PTGS2, PPARG, BTC, FOXO1, SOX9, CD24A, ADORA1, TGFB2, ALDH1A2, BDNF, SPRY1, S1PR1, CDKN2B, HEY2, GRPR, ADAM33, PTGER2, BMP2, ICOSL, IL7, EFNB1, ESR2, IRS1, EREG, EPGN, PLAU, BMPR1A |
| GO:0042445 | hormone metabolic process | 12 | 1.10−3 | 8.10−7 | ALDH1A2, ACE, RDH10, DIO2, AKR1C18, HSD17B1, CHST8, HSD11B2, ADH7, BMPR1B, PCSK5, CYP19A1 |
| GO:0040007 | growth | 16 | 5.10−3 | 3.10−6 | FGFR2, BMP2, PTGS2, GJA1, MREG, SOX9, TIMP3, TGFB2, RDH10, EREG, MFSD7B, ETNK2, BMPR1B, BMPR1A, CYP19A1, ADD1 |
| GO:0016337 | cell–cell adhesion | 17 | 1.10−2 | 8.10−6 | CDK5R1, CLSTN2, LMO7, PCDH8, CLDN11, PCDH7, MCAM, SOX9, CD24A, GPR98, TGFB2, PCDH18, AMIGO2, PVRL1, FREM2, ACAN, BMPR1B |
| GO:0001568 | blood vessel development | 17 | 2.10−2 | 1.10−5 | FGFR2, FGF18, TBX20, FOXO1, GJA1, CXCL12, TGFB2, ALDH1A2, S1PR1, EREG, EPGN, ITGA7, HEY2, ROBO4, ANGPT1, COL1A1, ANGPT2 |
| GO:0048589 | developmental growth | 11 | 3.10−2 | 2.10−5 | FGFR2, RDH10, EREG, PTGS2, GJA1, BMPR1B, MREG, SOX9, TIMP3, BMPR1A, CYP19A1 |
| GO:0001944 | vasculature development | 17 | 3.10−2 | 2.10−5 | FGFR2, FGF18, TBX20, FOXO1, GJA1, CXCL12, TGFB2, ALDH1A2, S1PR1, EREG, EPGN, ITGA7, HEY2, ROBO4, ANGPT1, COL1A1, ANGPT2 |
| GO:0048608 | reproductive structure development | 12 | 5.10−2 | 3.10−5 | FGFR2, DHH, RDH10, EREG, FST, ADAMTS1, ESR2, BMPR1B, VGF, SOX9, LFNG, CYP19A1 |
| PANTHER CLASSIFICATION of FOXL2 target genes | |||||
| BP00274 | Cell communication | 31 | 7.10−4 | 6.10−6 | CXCL5, CLSTN2, PPARG, BTC, FOXO1, CNTNAP5A, ASGR1, ASGR2, WISP2, BDNF, PVRL1, ADAM2, ANGPT1, HTR1D, ANGPT2, ODZ4, SLC8A1, IL7, EFEMP2, PCDH8, ESR2, PCDH7, GPR98, ARHGAP26, PCDH18, OMD, FREM2, EPGN, VCAN, PLAU, IGFBP4 |
| BP00102 | Signal transduction | 70 | 2.10−3 | 1.10−5 | NRP2, NDST4, CLSTN2, BTC, PPARG, GJA1, FOXO1, CNTNAP5A, ASGR1, ASGR2, BDNF, WISP2, S1PR1, GAB2, CXCR7, ADAM2, PDE4B, STARD8, ANGPT1, CHST15, HTR1D, RAMP1, ANGPT2, CCRL1, ODZ4, PTGER2, ARHGEF7, PCDH8, ESR2, PCDH7, IRS1, GPR98, ARHGAP26, AMIGO2, PLCE1, EREG, LYST, VCAN, RASD1, CAMK1D, FGFR2, IL1R1, CXCL5, SAV1, HS3ST1, PVRL1, GRPR, PCSK5, OLFM1, PIK3R1, SLC8A1, IL7, RASEF, EFEMP2, SPSB4, VMN2R11, SHANK2, RCAN2, PCDH18, DUSP5, EPHA4, OMD, RPS6KA1, RGS2, EPGN, FREM2, RGS4, BMPR1B, PLAU, IGFBP4 |
| GO TERM ENRICHMENT of the ‘in vivo’ FOXL2 target (71 genes at the intersection between our data and Ulenhaut's 2009) | |||||
| GO:0010817 | regulation of hormone levels | 7 | 1.10−2 | 2.10−5 | HSD17B1, CHST8, HSD11B2, EXOC3L, BMPR1B, PCSK5, CYP19A1 |
| GO:0042445 | hormone metabolic process | 6 | 3.10−2 | 4.10−5 | HSD17B1, CHST8, HSD11B2, BMPR1B, PCSK5, CYP19A1 |
Gene lists (FOXL2 targets or FOXL2 targets shared with Uhlenhaut et al., 2009) were analysed using the DAVID server (david.abcc.ncifcrf.gov/) to find significantly enriched terms among the GO Biological Process and Panther Biological Process databases. Only terms enriched with a Bonferroni p-value <0.05 were retained.