Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Wax clearance
Systematic review	146 ears (number of people not clear) 3 RCTs in this analysis	Proportion of ears clear of wax 15 minutes 11/76 (14%) with docusate sodium (water-based) 13/70 (19%) with triethanolamine polypeptide (water-based)	OR 0.8 95% CI 0.2 to 2.8 See below		Not significant
Systematic review	96 people 2 RCTs in this analysis	Syringing not necessary 6/45 (13%) with docusate-based proprietary preparation 11/51 (21%) with triethanolamine polypeptide-based proprietary preparation	OR 1.77 95% CI 0.62 to 5.11 Included 2 of the 3 RCTs included in the above analysis		Not significant
Systematic review	69 people, 138 ears Data from 1 RCT	Wax clearance with aqueous sodium bicarbonate (water-based) with acetic acid (water-based) Absolute results not reported	Reported as not significant P value not reported		Not significant